Insane Cookie Clicker Combo (x10 billion CPS)
This combo can be done in a vanilla game without scripts, but it requires good reaction speed and predetermining outcomes of the spell by trial and error (which also depend on how many golden cookies there are on screen at the moment). Order of the outcomes is constant and depends on a seed of the game, it changes each ascension.
If performed successfully, this can bring your progress from mid-game to late-game in no time!
Sugar Frenzy x3
Elder Frenzy x666
Golden Switch x1.5
Click Frenzy x777
Total boost activated: x10^10
Clicking boost activated: x45688
Music by C418 – Cookie Clicker OST